gene_symbol
TOP1
hgnc_id
HGNC:11986
binding_type
other
cytotoxicity
NO
cytotoxicity_type
INDIRECT
cytotoxicity_mechanism
The ADC targets TROP2 on tumor cells for delivery; after internalization, it releases tirumotecan, which inhibits DNA topoisomerase I to block DNA replication and induce apoptosis. Topoisomerase I is the payload’s enzymatic target, not the targeting antigen.
enzyme_product
On
epitope
Off
variant
Off
isoform
Off
hla_specific
Off
gated
Off
other_modifier
Target of released payload tirumotecan
trial_id_tar_ref
drug_id_tar_ref
disease_id_tar_ref
nct_id_tar_ref
NCT05319730
disease_id_num_tar_ref
2457
drug_id_num_tar_ref
6569