gene_symbol
CD22
hgnc_id
HGNC:1643
binding_type
antigen recognition
cytotoxicity
YES
cytotoxicity_type
DIRECT
cytotoxicity_mechanism
Bispecific CAR-T cells bind CD22 on target cells, triggering CD3ΞΆ/costimulatory signaling and immune synapse formation, leading to perforin/granzyme-mediated lysis (and death-receptor apoptosis).
enzyme_product
Off
epitope
Off
variant
Off
isoform
Off
hla_specific
Off
gated
Off
other_modifier
Tandem/bispecific CAR; recognition provides OR-logic with CD19
trial_id_tar_ref
drug_id_tar_ref
disease_id_tar_ref
nct_id_tar_ref
NCT06752785
disease_id_num_tar_ref
228
drug_id_num_tar_ref
647