gene_symbol
SLAMF7
hgnc_id
HGNC:21394
binding_type
antigen recognition
cytotoxicity
YES
cytotoxicity_type
DIRECT
cytotoxicity_mechanism
Elotuzumab binds SLAMF7 on target cells and engages NK cells via its Fc (FcγRIIIa), triggering antibody-dependent cellular cytotoxicity; it also activates NK cells, leading to killing of SLAMF7+ cells.
enzyme_product
Off
epitope
On
variant
Off
isoform
Off
hla_specific
Off
gated
Off
other_modifier
Cell-surface glycoprotein highly expressed on multiple myeloma cells and NK cells; mediates ADCC via Fc-FcγR interactions
trial_id_tar_ref
drug_id_tar_ref
disease_id_tar_ref
nct_id_tar_ref
NCT06232707
disease_id_num_tar_ref
2458
drug_id_num_tar_ref
6579