gene_symbol
EGFR
hgnc_id
HGNC:3236
binding_type
antigen recognition
cytotoxicity
YES
cytotoxicity_type
DIRECT
cytotoxicity_mechanism
Cetuximab’s IgG1 Fc engages Fcγ receptors on NK cells and other effectors to trigger ADCC (and some complement-mediated lysis), killing EGFR-expressing cells; EGFR blockade itself is primarily cytostatic.
enzyme_product
On
epitope
On
variant
Off
isoform
Off
hla_specific
Off
gated
Off
other_modifier
Binds extracellular domain (domain III); blocks ligand binding and receptor dimerization
trial_id_tar_ref
drug_id_tar_ref
disease_id_tar_ref
nct_id_tar_ref
NCT06428500
disease_id_num_tar_ref
2464
drug_id_num_tar_ref
6598