gene_symbol
CD38
hgnc_id
HGNC:1667
binding_type
antigen recognition
cytotoxicity
YES
cytotoxicity_type
DIRECT
cytotoxicity_mechanism
When Astatine-211 is conjugated to a CD38-targeting antibody, it binds CD38+ cells and emits short-range, high-LET alpha particles that induce clustered DNA double-strand breaks, causing rapid cell death.
enzyme_product
Off
epitope
Off
variant
Off
isoform
Off
hla_specific
Off
gated
Off
other_modifier
Targeted by OKT10-B10 anti-CD38 antibody conjugated to 211At
trial_id_tar_ref
drug_id_tar_ref
disease_id_tar_ref
nct_id_tar_ref
NCT04466475
disease_id_num_tar_ref
2474
drug_id_num_tar_ref
6621