gene_symbol
CD276
hgnc_id
HGNC:19137
binding_type
antigen recognition
cytotoxicity
YES
cytotoxicity_type
DIRECT
cytotoxicity_mechanism
ADC binds B7-H3 on target cells, is internalized, and releases a cytotoxic (likely topoisomerase I inhibitor) payload that induces DNA damage leading to cell death.
enzyme_product
Off
epitope
Off
variant
Off
isoform
Off
hla_specific
Off
gated
Off
other_modifier
Inferred from protocol exclusions; not explicitly confirmed in the trial description.
trial_id_tar_ref
drug_id_tar_ref
disease_id_tar_ref
nct_id_tar_ref
NCT06008379
disease_id_num_tar_ref
2475
drug_id_num_tar_ref
6625