gene_symbol
CD276
hgnc_id
HGNC:19137
binding_type
antigen recognition
cytotoxicity
YES
cytotoxicity_type
DIRECT
cytotoxicity_mechanism
CAR-T cells recognize CD276 on target cells, triggering CD3ΞΆ/costimulatory signaling and T-cell cytotoxicity via perforin/granzyme release (with cytokine-mediated effects).
enzyme_product
Off
epitope
Off
variant
Off
isoform
Off
hla_specific
Off
gated
Off
other_modifier
B7 family immune checkpoint expressed on glioblastoma cells and tumor vasculature
trial_id_tar_ref
drug_id_tar_ref
disease_id_tar_ref
nct_id_tar_ref
NCT06691308
disease_id_num_tar_ref
230
drug_id_num_tar_ref
651