gene_symbol
TOP1
hgnc_id
HGNC:11986
binding_type
other
cytotoxicity
NO
cytotoxicity_type
INDIRECT
cytotoxicity_mechanism
7MW3711 is an ADC that binds a surface antigen (likely B7-H3/CD276), is internalized, and releases a topoisomerase I inhibitor payload that induces DNA damage. Killing depends on the surface antigen, not on topoisomerase I expression itself.
enzyme_product
On
epitope
Off
variant
Off
isoform
Off
hla_specific
Off
gated
Off
other_modifier
Likely payload target (topoisomerase I inhibitor ADC), inferred from protocol exclusions; not explicitly confirmed.
trial_id_tar_ref
drug_id_tar_ref
disease_id_tar_ref
nct_id_tar_ref
NCT06008379
disease_id_num_tar_ref
2475
drug_id_num_tar_ref
6625