gene_symbol
GPRC5D
hgnc_id
HGNC:13310
binding_type
antigen recognition
cytotoxicity
YES
cytotoxicity_type
DIRECT
cytotoxicity_mechanism
Talquetamab crosslinks CD3 on T cells to GPRC5D on target cells, activating T cells to form an immunologic synapse and kill GPRC5D+ cells via perforin/granzyme release.
enzyme_product
Off
epitope
On
variant
Off
isoform
Off
hla_specific
Off
gated
Off
other_modifier
Tumor-associated antigen on myeloma/plasma cells
trial_id_tar_ref
drug_id_tar_ref
disease_id_tar_ref
nct_id_tar_ref
NCT05849610
disease_id_num_tar_ref
2477
drug_id_num_tar_ref
6632