gene_symbol
CD3E
hgnc_id
HGNC:1674
binding_type
antigen recognition
cytotoxicity
NO
cytotoxicity_type
INDIRECT
cytotoxicity_mechanism
Talquetamab binds CD3 on T cells to activate and redirect them to GPRC5D+ tumor cells; the T cells then kill GPRC5D-expressing cells via perforin/granzyme release, not the CD3+ cells.
enzyme_product
Off
epitope
On
variant
Off
isoform
Off
hla_specific
Off
gated
Off
other_modifier
T-cell receptor complex component
trial_id_tar_ref
drug_id_tar_ref
disease_id_tar_ref
nct_id_tar_ref
NCT05849610
disease_id_num_tar_ref
2477
drug_id_num_tar_ref
6632