gene_symbol
GPRC5D
hgnc_id
HGNC:13310
binding_type
antigen recognition
cytotoxicity
YES
cytotoxicity_type
DIRECT
cytotoxicity_mechanism
The antibody binds GPRC5D on myeloma cells and its Fc engages Fc gamma receptors (e.g., CD16) on NK cells to trigger ADCC (perforin/granzyme), with possible ADCP/CDC.
enzyme_product
Off
epitope
Off
variant
Off
isoform
Off
hla_specific
Off
gated
Off
other_modifier
cell-surface GPCR on malignant plasma cells
trial_id_tar_ref
drug_id_tar_ref
disease_id_tar_ref
nct_id_tar_ref
NCT06630806
disease_id_num_tar_ref
2484
drug_id_num_tar_ref
6645