gene_symbol
CLDN18
hgnc_id
HGNC:2039
binding_type
antigen recognition
cytotoxicity
YES
cytotoxicity_type
DIRECT
cytotoxicity_mechanism
Bispecific T‑cell engager binds CLDN18.2 on tumor cells and CD3 on T cells, crosslinking to activate CTLs and form an immune synapse, leading to perforin/granzyme-mediated lysis of CLDN18.2+ cells (with potential bystander killing).
enzyme_product
Off
epitope
Off
variant
Off
isoform
On
hla_specific
Off
gated
Off
other_modifier
Bivalent high-affinity binding to tumor-associated antigen
trial_id_tar_ref
drug_id_tar_ref
disease_id_tar_ref
nct_id_tar_ref
NCT06005493
disease_id_num_tar_ref
2485
drug_id_num_tar_ref
6646