gene_symbol
UNKNOWN
binding_type
other
cytotoxicity
NO
cytotoxicity_type
INDIRECT
cytotoxicity_mechanism
The ADC binds B7-H3 on tumor cells, is internalized, and releases a topoisomerase inhibitor that blocks DNA topoisomerase, causing replication arrest and apoptosis; Fc may also trigger ADCC/ADCP. DNA topoisomerase itself is not the targeting determinant.
enzyme_product
On
epitope
Off
variant
Off
isoform
Off
hla_specific
Off
gated
Off
other_modifier
Topoisomerase type not specified in trial materials
trial_id_tar_ref
drug_id_tar_ref
disease_id_tar_ref
nct_id_tar_ref
NCT06112704
disease_id_num_tar_ref
2486
drug_id_num_tar_ref
6647