gene_symbol
SIRPA
hgnc_id
HGNC:9662
binding_type
receptor ligand recognition
cytotoxicity
NO
cytotoxicity_type
INDIRECT
cytotoxicity_mechanism
SC291 CAR T cells target CD19, not SIRPα; they kill CD19+ cells via T-cell–mediated cytolysis (perforin/granzyme). CD47 on the CAR T cells engages SIRPα on myeloid cells to inhibit phagocytosis, so SIRPα+ cells are not targeted for killing.
enzyme_product
Off
epitope
Off
variant
Off
isoform
Off
hla_specific
Off
gated
Off
other_modifier
Immune evasion via CD47–SIRPα interaction
trial_id_tar_ref
drug_id_tar_ref
disease_id_tar_ref
nct_id_tar_ref
NCT05878184
disease_id_num_tar_ref
2488
drug_id_num_tar_ref
6649