gene_symbol
TNF
hgnc_id
HGNC:11892
binding_type
antigen recognition
cytotoxicity
YES
cytotoxicity_type
DIRECT
cytotoxicity_mechanism
By binding transmembrane TNF-α, CT-P13 triggers reverse-signaling apoptosis and engages Fc-mediated effector functions (ADCC via NK cells and CDC), killing TNF-α–expressing cells.
enzyme_product
Off
epitope
Off
variant
Off
isoform
Off
hla_specific
Off
gated
Off
other_modifier
transmembrane form
trial_id_tar_ref
drug_id_tar_ref
disease_id_tar_ref
nct_id_tar_ref
NCT05866614
disease_id_num_tar_ref
2496
drug_id_num_tar_ref
6676