gene_symbol
CD33
hgnc_id
HGNC:1659
binding_type
antigen recognition
cytotoxicity
YES
cytotoxicity_type
DIRECT
cytotoxicity_mechanism
CD33-specific CAR T cells bind CD33 on target cells, triggering T-cell activation and perforin/granzyme-mediated killing (with possible death receptor pathways), leading to apoptosis of CD33+ cells.
enzyme_product
Off
epitope
Off
variant
Off
isoform
Off
hla_specific
Off
gated
Off
other_modifier
Myeloid lineage cell-surface receptor; HLA-independent CAR binding
trial_id_tar_ref
drug_id_tar_ref
disease_id_tar_ref
nct_id_tar_ref
NCT06420063
disease_id_num_tar_ref
2506
drug_id_num_tar_ref
6698