gene_symbol
CD274
hgnc_id
HGNC:17635
binding_type
antigen recognition
cytotoxicity
YES
cytotoxicity_type
DIRECT
cytotoxicity_mechanism
Avelumab binds PD-L1 on target cells and, via its IgG1 Fc, engages Fc-gamma receptors on NK cells (and other effector cells) to mediate antibody-dependent cellular cytotoxicity (ADCC), killing PD-L1-expressing cells.
enzyme_product
Off
epitope
Off
variant
Off
isoform
Off
hla_specific
Off
gated
Off
other_modifier
Blocks PD-L1 interaction with PD-1; IgG1 Fc can engage FcγRIIIa (CD16a) to mediate ADCC.
trial_id_tar_ref
drug_id_tar_ref
disease_id_tar_ref
nct_id_tar_ref
NCT05222932
disease_id_num_tar_ref
2519
drug_id_num_tar_ref
6729