gene_symbol
SLAMF7
hgnc_id
HGNC:21394
binding_type
antigen recognition
cytotoxicity
YES
cytotoxicity_type
DIRECT
cytotoxicity_mechanism
Elotuzumab binds SLAMF7 on myeloma cells and engages Fcγ receptors on NK cells to trigger ADCC; it also activates NK cells via SLAMF7 signaling, leading to immune-mediated killing of SLAMF7+ cells.
enzyme_product
Off
epitope
Off
variant
Off
isoform
Off
hla_specific
Off
gated
Off
other_modifier
Also known as CRACC/CD319; cell-surface receptor on myeloma and NK cells
trial_id_tar_ref
drug_id_tar_ref
disease_id_tar_ref
nct_id_tar_ref
NCT05981209
disease_id_num_tar_ref
2533
drug_id_num_tar_ref
6761