gene_symbol
CCR4
hgnc_id
HGNC:1605
binding_type
antigen recognition
cytotoxicity
YES
cytotoxicity_type
DIRECT
cytotoxicity_mechanism
Antibody binds CCR4 on target cells; its defucosylated IgG1 Fc engages FcγRIIIa on NK cells to trigger antibody-dependent cellular cytotoxicity (ADCC), leading to lysis/apoptosis of CCR4+ cells.
enzyme_product
Off
epitope
Off
variant
Off
isoform
Off
hla_specific
Off
gated
Off
other_modifier
Alias: CD194
trial_id_tar_ref
drug_id_tar_ref
disease_id_tar_ref
nct_id_tar_ref
NCT05414500
disease_id_num_tar_ref
2543
drug_id_num_tar_ref
6799