gene_symbol
ERBB2
hgnc_id
HGNC:3430
binding_type
antigen recognition
cytotoxicity
YES
cytotoxicity_type
DIRECT
cytotoxicity_mechanism
HER2-targeted ADC binds HER2, is internalized, then releases MMAE that disrupts microtubules (tubulin inhibition), causing G2/M arrest and apoptosis; may also trigger ADCC/bystander killing.
enzyme_product
On
epitope
Off
variant
Off
isoform
Off
hla_specific
Off
gated
Off
other_modifier
Antibody moiety of ADC binds HER2 on tumor cells
trial_id_tar_ref
drug_id_tar_ref
disease_id_tar_ref
nct_id_tar_ref
NCT06560528
disease_id_num_tar_ref
237
drug_id_num_tar_ref
670