gene_symbol
TNFRSF8
hgnc_id
HGNC:11923
binding_type
antigen recognition
cytotoxicity
YES
cytotoxicity_type
DIRECT
cytotoxicity_mechanism
Anti-CD30 antibody–drug conjugate binds CD30, is internalized, and releases MMAE intracellularly, inhibiting microtubule polymerization to cause G2/M arrest and apoptosis (with some Fc-mediated ADCC).
enzyme_product
Off
epitope
Off
variant
Off
isoform
Off
hla_specific
Off
gated
Off
other_modifier
Cell-surface TNF receptor targeted by the antibody component
trial_id_tar_ref
drug_id_tar_ref
disease_id_tar_ref
nct_id_tar_ref
NCT05414500
disease_id_num_tar_ref
2543
drug_id_num_tar_ref
6800