gene_symbol
TUBB
hgnc_id
HGNC:20778
binding_type
other
cytotoxicity
NO
cytotoxicity_type
INDIRECT
cytotoxicity_mechanism
The ADC binds CD30 (not beta‑tubulin), is internalized, and releases MMAE, which then binds beta‑tubulin to inhibit microtubule polymerization and trigger G2/M arrest and apoptosis. Thus only CD30+ cells are killed; beta‑tubulin expression alone is not sufficient.
enzyme_product
Off
epitope
Off
variant
Off
isoform
Off
hla_specific
Off
gated
Off
other_modifier
MMAE payload binds the vinca site on β-tubulin to inhibit microtubule polymerization
trial_id_tar_ref
drug_id_tar_ref
disease_id_tar_ref
nct_id_tar_ref
NCT05414500
disease_id_num_tar_ref
2543
drug_id_num_tar_ref
6800