gene_symbol
TNFRSF17
hgnc_id
HGNC:11913
binding_type
antigen recognition
cytotoxicity
YES
cytotoxicity_type
DIRECT
cytotoxicity_mechanism
BCMA-directed CAR T cells bind BCMA on target cells, activate via CD3ΞΆ/4-1BB signaling, and kill through perforin/granzyme-mediated cytolysis and apoptosis pathways.
enzyme_product
Off
epitope
Off
variant
Off
isoform
Off
hla_specific
Off
gated
Off
other_modifier
Membrane-bound, cell-surface receptor on malignant plasma cells; HLA-independent recognition
trial_id_tar_ref
drug_id_tar_ref
disease_id_tar_ref
nct_id_tar_ref
NCT06045806
disease_id_num_tar_ref
2551
drug_id_num_tar_ref
6817