gene_symbol
MS4A1
hgnc_id
HGNC:7315
binding_type
antigen recognition
cytotoxicity
YES
cytotoxicity_type
DIRECT
cytotoxicity_mechanism
The adaptor MicAbody (MA-20/ASP101G) binds CD20 on target cells and engages the NKG2D-based convertible CAR on ASP2802 T cells via a ULBP2 ligand, activating the CAR T cells to kill CD20+ cells via cytotoxic T-cell mechanisms (e.g., perforin/granzyme-mediated lysis).
enzyme_product
Off
epitope
Off
variant
Off
isoform
Off
hla_specific
Off
gated
On
other_modifier
Engagement occurs via the MA-20 (ASP101G) MicAbody adaptor; ASP2802 does not bind CD20 directly.
trial_id_tar_ref
drug_id_tar_ref
disease_id_tar_ref
nct_id_tar_ref
NCT06248086
disease_id_num_tar_ref
21
drug_id_num_tar_ref
50