gene_symbol
CD38
hgnc_id
HGNC:1667
binding_type
antigen recognition
cytotoxicity
YES
cytotoxicity_type
DIRECT
cytotoxicity_mechanism
Daratumumab binds CD38 on target cells and induces Fc-mediated killing—NK-cell ADCC (via CD16), macrophage ADCP, and complement-dependent cytotoxicity (CDC); it can also trigger apoptosis upon crosslinking.
enzyme_product
On
epitope
Off
variant
Off
isoform
Off
hla_specific
Off
gated
Off
other_modifier
Type II transmembrane ectoenzyme (NADase/ADP-ribosyl cyclase)
trial_id_tar_ref
drug_id_tar_ref
disease_id_tar_ref
nct_id_tar_ref
NCT06119685
disease_id_num_tar_ref
2570
drug_id_num_tar_ref
6865