gene_symbol
KIT
hgnc_id
HGNC:6342
binding_type
antigen recognition
cytotoxicity
YES
cytotoxicity_type
DIRECT
cytotoxicity_mechanism
Binds CD117 and blocks SCF–KIT survival signaling, causing depletion/apoptosis of KIT+ hematopoietic stem cells; Fc engagement can recruit immune effectors (ADCC/ADCP) to kill bound cells.
enzyme_product
On
epitope
Off
variant
Off
isoform
Off
hla_specific
Off
gated
Off
other_modifier
Blocks stem cell factor (SCF/KITLG) binding and KIT signaling
trial_id_tar_ref
drug_id_tar_ref
disease_id_tar_ref
nct_id_tar_ref
NCT06145282
disease_id_num_tar_ref
2576
drug_id_num_tar_ref
6885