gene_symbol
CD38
hgnc_id
HGNC:1667
binding_type
antigen recognition
cytotoxicity
YES
cytotoxicity_type
DIRECT
cytotoxicity_mechanism
Felzartamab binds CD38 on target cells and recruits immune effectors via its Fc to induce ADCC (NK cells), ADCP (phagocytes), and complement-dependent cytotoxicity, causing lysis of CD38+ cells.
enzyme_product
On
epitope
Off
variant
Off
isoform
Off
hla_specific
Off
gated
Off
other_modifier
Membrane ectoenzyme (NADase/ADP-ribosyl cyclase) on plasma cells/plasmablasts
trial_id_tar_ref
drug_id_tar_ref
disease_id_tar_ref
nct_id_tar_ref
NCT06064929
disease_id_num_tar_ref
2580
drug_id_num_tar_ref
6897