gene_symbol
MS4A1
hgnc_id
HGNC:7315
binding_type
antigen recognition
cytotoxicity
YES
cytotoxicity_type
DIRECT
cytotoxicity_mechanism
Anti-CD20 antibody binds CD20 on B cells and engages immune effectors via its Fc: NK cell–mediated ADCC, complement-dependent cytotoxicity (C1q activation/lysis), and macrophage phagocytosis; can also trigger apoptosis.
enzyme_product
Off
epitope
On
variant
Off
isoform
Off
hla_specific
Off
gated
Off
other_modifier
Type I anti-CD20; binds a conformational epitope on the large extracellular loop; glycosylation-independent
trial_id_tar_ref
drug_id_tar_ref
disease_id_tar_ref
nct_id_tar_ref
NCT05939037
disease_id_num_tar_ref
2583
drug_id_num_tar_ref
6905