gene_symbol
MMP2
hgnc_id
HGNC:7166
binding_type
antigen recognition
cytotoxicity
YES
cytotoxicity_type
DIRECT
cytotoxicity_mechanism
CLTX-based CAR on the T cells binds the MMP2-associated surface complex, triggering CD28/CD3zeta signaling and T-cell cytotoxicity via perforin/granzyme release (and Fas–FasL), killing the target cells.
enzyme_product
Off
epitope
Off
variant
Off
isoform
Off
hla_specific
Off
gated
Off
other_modifier
Binding is MMP2-dependent within a tumor cell surface MMP2-associated complex recognized by the chlorotoxin (CLTX) domain
trial_id_tar_ref
drug_id_tar_ref
disease_id_tar_ref
nct_id_tar_ref
NCT05627323
disease_id_num_tar_ref
2587
drug_id_num_tar_ref
6917