gene_symbol
TRAC
hgnc_id
HGNC:12029
binding_type
other
cytotoxicity
NO
cytotoxicity_type
INDIRECT
cytotoxicity_mechanism
These CAR-T cells kill CD19+ B cells via CAR-mediated cytotoxicity (perforin/granzyme apoptosis). TRAC is knocked out in the CAR-T product and is not a recognized target; TRAC-expressing cells are not directly targeted or killed.
enzyme_product
Off
epitope
Off
variant
Off
isoform
Off
hla_specific
Off
gated
Off
other_modifier
CRISPR knockout to eliminate endogenous TCR and reduce GVHD
trial_id_tar_ref
disease_id_tar_ref
nct_id_tar_ref
NCT06014073
disease_id_num_tar_ref
2592
drug_id_num_tar_ref
6925