gene_symbol
SPPL3
hgnc_id
HGNC:30424
binding_type
other
cytotoxicity
NO
cytotoxicity_type
INDIRECT
cytotoxicity_mechanism
SPPL3 is not targeted by the CAR; the CAR-T cells kill only CD19+ cells via T-cell cytolysis (perforin/granzyme, Fas/FasL). SPPL3 is knocked out in the CAR-T cells to reduce immunogenicity and does not mediate target-cell killing.
enzyme_product
On
epitope
Off
variant
Off
isoform
Off
hla_specific
Off
gated
Off
other_modifier
CRISPR knockout (Power3) to alter Golgi glycosylation and enable glycan shielding
trial_id_tar_ref
disease_id_tar_ref
nct_id_tar_ref
NCT06014073
disease_id_num_tar_ref
2592
drug_id_num_tar_ref
6925