gene_symbol
TNFRSF8
hgnc_id
HGNC:11923
binding_type
antigen recognition
cytotoxicity
YES
cytotoxicity_type
DIRECT
cytotoxicity_mechanism
An anti-CD30 ADC binds CD30, is internalized, and releases MMAE intracellularly to inhibit microtubules, causing G2/M arrest and apoptosis; can also mediate ADCC and bystander killing.
enzyme_product
Off
epitope
Off
variant
Off
isoform
Off
hla_specific
Off
gated
Off
other_modifier
Cell-surface receptor; ADC binding triggers internalization and lysosomal release of MMAE
trial_id_tar_ref
drug_id_tar_ref
disease_id_tar_ref
nct_id_tar_ref
NCT05886478
disease_id_num_tar_ref
2598
drug_id_num_tar_ref
6934