gene_symbol
TNFRSF8
hgnc_id
HGNC:11923
binding_type
antigen recognition
cytotoxicity
YES
cytotoxicity_type
DIRECT
cytotoxicity_mechanism
Anti-CD30 ADC binds CD30, is internalized, linker is cleaved to release MMAE, which inhibits tubulin polymerization causing G2/M arrest and apoptosis (with possible bystander effect).
enzyme_product
Off
epitope
On
variant
Off
isoform
Off
hla_specific
Off
gated
Off
other_modifier
Cell-surface TNF receptor; antibody component of ADC binds CD30 to enable internalization.
trial_id_tar_ref
drug_id_tar_ref
disease_id_tar_ref
nct_id_tar_ref
NCT05313243
disease_id_num_tar_ref
2604
drug_id_num_tar_ref
6955