gene_symbol
TUBB
hgnc_id
HGNC:20778
binding_type
other
cytotoxicity
NO
cytotoxicity_type
INDIRECT
cytotoxicity_mechanism
Brentuximab vedotin targets CD30, is internalized, and releases MMAE, which inhibits beta-tubulin polymerization to cause mitotic arrest and apoptosis; beta-tubulin is affected only after CD30-mediated delivery (possible bystander effect).
enzyme_product
Off
epitope
Off
variant
Off
isoform
Off
hla_specific
Off
gated
Off
other_modifier
Intracellular payload MMAE binds the Vinca site to inhibit microtubule polymerization.
trial_id_tar_ref
drug_id_tar_ref
disease_id_tar_ref
nct_id_tar_ref
NCT05313243
disease_id_num_tar_ref
2604
drug_id_num_tar_ref
6955