gene_symbol
TOP1
hgnc_id
HGNC:11986
binding_type
other
cytotoxicity
NO
cytotoxicity_type
INDIRECT
cytotoxicity_mechanism
The ADC targets HER2 (not topoisomerase I) on tumor cells, is internalized, and releases deruxtecan, which inhibits Topo I to cause DNA damage and apoptosis (with bystander killing). Cell kill is determined by HER2-mediated delivery, not by expression of Topo I itself.
enzyme_product
On
epitope
Off
variant
Off
isoform
Off
hla_specific
Off
gated
Off
other_modifier
Payload target (DXd; Topo I inhibitor)
trial_id_tar_ref
drug_id_tar_ref
disease_id_tar_ref
nct_id_tar_ref
NCT05950945
disease_id_num_tar_ref
2616
drug_id_num_tar_ref
6981