gene_symbol
ERBB2
hgnc_id
HGNC:3430
binding_type
antigen recognition
cytotoxicity
YES
cytotoxicity_type
DIRECT
cytotoxicity_mechanism
IgG1 anti-HER2 antibody binds HER2 on tumor cells and engages Fcγ receptors on effector cells to trigger antibody-dependent cellular cytotoxicity (ADCC), killing HER2+ cells (potentially with some complement involvement).
enzyme_product
On
epitope
Off
variant
Off
isoform
Off
hla_specific
Off
gated
Off
other_modifier
Binds extracellular domain; mediates ADCC via Fc-gamma interactions
trial_id_tar_ref
drug_id_tar_ref
disease_id_tar_ref
nct_id_tar_ref
NCT06532006
disease_id_num_tar_ref
2619
drug_id_num_tar_ref
6985