gene_symbol
CD3E
hgnc_id
HGNC:1674
binding_type
antigen recognition
cytotoxicity
NO
cytotoxicity_type
INDIRECT
cytotoxicity_mechanism
The bispecific antibody binds CD3ε on T cells and DLL3 on tumor cells, activating T cells to kill DLL3-expressing tumor cells via immune synapse and perforin–granzyme release; CD3ε+ T cells are not targeted for killing.
enzyme_product
Off
epitope
Off
variant
Off
isoform
Off
hla_specific
Off
gated
Off
other_modifier
T-cell receptor-CD3 complex component on T cells
trial_id_tar_ref
drug_id_tar_ref
disease_id_tar_ref
nct_id_tar_ref
NCT06132113
disease_id_num_tar_ref
2630
drug_id_num_tar_ref
7014