gene_symbol
FCGR3A
hgnc_id
HGNC:3619
binding_type
receptor ligand recognition
cytotoxicity
NO
cytotoxicity_type
INDIRECT
cytotoxicity_mechanism
Obinutuzumab binds CD20 on B cells; its afucosylated Fc engages CD16a on NK cells/macrophages to drive ADCC/ADCP and direct cell death of CD20+ B cells. CD16a+ effector cells are not targeted or killed.
enzyme_product
Off
epitope
Off
variant
Off
isoform
Off
hla_specific
Off
gated
Off
other_modifier
Fc-mediated binding; afucosylated IgG1 Fc increases affinity and enhances ADCC/ADCP
trial_id_tar_ref
drug_id_tar_ref
disease_id_tar_ref
nct_id_tar_ref
NCT06191744
disease_id_num_tar_ref
2634
drug_id_num_tar_ref
7027