gene_symbol
FCGR3B
hgnc_id
HGNC:3620
binding_type
receptor ligand recognition
cytotoxicity
NO
cytotoxicity_type
INDIRECT
cytotoxicity_mechanism
CD16b is an Fc receptor on effector cells (e.g., neutrophils). Obinutuzumab targets CD20 on B cells and uses its Fc to engage Fcγ receptors (e.g., CD16) to drive ADCC/ADCP against CD20+ cells; CD16b+ cells are not the targets killed.
enzyme_product
Off
epitope
Off
variant
Off
isoform
Off
hla_specific
Off
gated
Off
other_modifier
Fc-mediated binding; afucosylated IgG1 Fc increases affinity
trial_id_tar_ref
drug_id_tar_ref
disease_id_tar_ref
nct_id_tar_ref
NCT06191744
disease_id_num_tar_ref
2634
drug_id_num_tar_ref
7027