gene_symbol
MICA
hgnc_id
HGNC:7090
binding_type
antigen recognition
cytotoxicity
YES
cytotoxicity_type
DIRECT
cytotoxicity_mechanism
NKG2D-CAR NK-92 cells bind MICA on target cells, triggering NK activation and immune synapse formation, leading to perforin/granzyme-mediated lysis of the MICA-expressing cells.
enzyme_product
Off
epitope
Off
variant
Off
isoform
Off
hla_specific
Off
gated
Off
other_modifier
stress-induced NKG2D ligand
trial_id_tar_ref
drug_id_tar_ref
disease_id_tar_ref
nct_id_tar_ref
NCT05528341
disease_id_num_tar_ref
2638
drug_id_num_tar_ref
7043