gene_symbol
TACSTD2
hgnc_id
HGNC:11530
binding_type
antigen recognition
cytotoxicity
YES
cytotoxicity_type
DIRECT
cytotoxicity_mechanism
The anti-TROP2 ADC binds TROP2, is internalized, and releases SN-38, which inhibits topoisomerase I, causing DNA damage and apoptosis (with possible bystander effect).
enzyme_product
Off
epitope
On
variant
Off
isoform
Off
hla_specific
Off
gated
Off
other_modifier
Cell-surface glycoprotein antigen targeted by the ADC antibody component
trial_id_tar_ref
drug_id_tar_ref
disease_id_tar_ref
nct_id_tar_ref
NCT07066917
disease_id_num_tar_ref
2649
drug_id_num_tar_ref
7062