gene_symbol
TOP1
hgnc_id
HGNC:11986
binding_type
other
cytotoxicity
NO
cytotoxicity_type
INDIRECT
cytotoxicity_mechanism
The ADC binds TROP2 (not topoisomerase I) and is internalized; the released SN-38 inhibits topoisomerase I to cause DNA damage and apoptosis. Thus, topoisomerase I expression alone does not determine targeting; killing occurs via TROP2-mediated delivery with possible bystander effect.
enzyme_product
On
epitope
Off
variant
Off
isoform
Off
hla_specific
Off
gated
Off
other_modifier
Enzyme inhibited by the SN-38 payload released from the ADC
trial_id_tar_ref
drug_id_tar_ref
disease_id_tar_ref
nct_id_tar_ref
NCT07066917
disease_id_num_tar_ref
2649
drug_id_num_tar_ref
7062