gene_symbol
ERBB2
hgnc_id
HGNC:3430
binding_type
antigen recognition
cytotoxicity
YES
cytotoxicity_type
DIRECT
cytotoxicity_mechanism
Pertuzumab opsonizes HER2-expressing cells and engages FcγR-bearing immune effectors (e.g., NK cells) to mediate ADCC; HER2 dimerization blockade can also trigger apoptosis.
enzyme_product
Off
epitope
On
variant
Off
isoform
Off
hla_specific
Off
gated
Off
other_modifier
Binds extracellular domain II (dimerization arm) to block HER2 heterodimerization with HER3/EGFR
trial_id_tar_ref
drug_id_tar_ref
disease_id_tar_ref
nct_id_tar_ref
NCT06162559
disease_id_num_tar_ref
2652
drug_id_num_tar_ref
7074