gene_symbol
TNFRSF8
hgnc_id
HGNC:11923
binding_type
antigen recognition
cytotoxicity
YES
cytotoxicity_type
DIRECT
cytotoxicity_mechanism
CD30-directed CAR on the infused T cells binds CD30 on target cells, activating T-cell cytotoxicity (perforin/granzyme and Fas–FasL) to kill CD30+ cells.
enzyme_product
Off
epitope
On
variant
Off
isoform
Off
hla_specific
Off
gated
Off
other_modifier
Cell-surface TNF receptor superfamily member (target of CAR)
trial_id_tar_ref
drug_id_tar_ref
disease_id_tar_ref
nct_id_tar_ref
NCT04952584
disease_id_num_tar_ref
2658
drug_id_num_tar_ref
7086