gene_symbol
CD3E
hgnc_id
HGNC:1674
binding_type
antigen recognition
cytotoxicity
NO
cytotoxicity_type
INDIRECT
cytotoxicity_mechanism
Epcoritamab engages CD3ε on T cells to activate them and bridge to CD20 on B cells; the activated T cells kill CD20+ B cells via perforin/granzyme. CD3ε+ T cells are not the cytotoxic target.
enzyme_product
Off
epitope
Off
variant
Off
isoform
Off
hla_specific
Off
gated
Off
other_modifier
Component of T-cell receptor/CD3 complex
trial_id_tar_ref
drug_id_tar_ref
disease_id_tar_ref
nct_id_tar_ref
NCT06510491
disease_id_num_tar_ref
2667
drug_id_num_tar_ref
7108