gene_symbol
ULBP2
hgnc_id
HGNC:14894
binding_type
receptor ligand recognition
cytotoxicity
NO
cytotoxicity_type
INDIRECT
cytotoxicity_mechanism
ULBP2 is the ligand on the adaptor that binds the NKG2D-based convertible CAR to activate T cells only when the adaptor also binds CD20 on tumor cells; the CAR T cells then kill CD20+ cells, not ULBP2-expressing cells.
enzyme_product
Off
epitope
Off
variant
On
isoform
Off
hla_specific
Off
gated
On
other_modifier
Orthogonal, engineered ULBP2 ligand on MA-20 that docks to the NKG2D-based convertible CAR on ASP2802.
trial_id_tar_ref
drug_id_tar_ref
disease_id_tar_ref
nct_id_tar_ref
NCT06248086
disease_id_num_tar_ref
21
drug_id_num_tar_ref
50