gene_symbol
ERBB2
hgnc_id
HGNC:3430
binding_type
antigen recognition
cytotoxicity
YES
cytotoxicity_type
DIRECT
cytotoxicity_mechanism
The ADC binds HER2, is internalized, and releases MMAE, which inhibits tubulin polymerization leading to microtubule disruption, G2/M arrest, and apoptosis; the antibody may also trigger ADCC.
enzyme_product
On
epitope
On
variant
Off
isoform
Off
hla_specific
Off
gated
Off
other_modifier
ADC antibody moiety (disitamab) binds extracellular domain of HER2
trial_id_tar_ref
drug_id_tar_ref
disease_id_tar_ref
nct_id_tar_ref
NCT05957757
disease_id_num_tar_ref
2677
drug_id_num_tar_ref
7128