gene_symbol
TUBB
hgnc_id
HGNC:20778
binding_type
other
cytotoxicity
NO
cytotoxicity_type
INDIRECT
cytotoxicity_mechanism
RC48 targets HER2 on the cell surface; after internalization it releases MMAE, which binds the vinca site on beta-tubulin to disrupt microtubules and induce G2/M arrest and apoptosis. Beta-tubulin itself is not the targeting antigen.
enzyme_product
Off
epitope
Off
variant
Off
isoform
Off
hla_specific
Off
gated
Off
other_modifier
MMAE payload binds beta-tubulin at the vinca site to inhibit microtubule polymerization
trial_id_tar_ref
drug_id_tar_ref
disease_id_tar_ref
nct_id_tar_ref
NCT05957757
disease_id_num_tar_ref
2677
drug_id_num_tar_ref
7128