gene_symbol
UNKNOWN
binding_type
antigen recognition
cytotoxicity
YES
cytotoxicity_type
DIRECT
cytotoxicity_mechanism
Fc-engineered anti-HBsAg antibody opsonizes HBsAg+ hepatocytes and engages Fcγ receptors on NK cells/macrophages to trigger ADCC/ADCP, leading to killing/clearance of target cells.
enzyme_product
Off
epitope
On
variant
Off
isoform
Off
hla_specific
Off
gated
Off
other_modifier
Neutralizes HBV virions and subviral particles; enables clearance of HBsAg-expressing hepatocytes via Fc effector functions
trial_id_tar_ref
drug_id_tar_ref
disease_id_tar_ref
nct_id_tar_ref
NCT05612581
disease_id_num_tar_ref
2679
drug_id_num_tar_ref
7131