gene_symbol
UNKNOWN
binding_type
receptor ligand recognition
cytotoxicity
NO
cytotoxicity_type
INDIRECT
cytotoxicity_mechanism
The antibody binds HBsAg on infected hepatocytes and uses its Fc to engage Fcγ receptors on NK cells/macrophages, triggering ADCC/ADCP that kills HBsAg+ hepatocytes; FcγR-expressing cells are not targeted for killing.
enzyme_product
Off
epitope
Off
variant
Off
isoform
Off
hla_specific
Off
gated
Off
other_modifier
Fc engineering enhances Fcγ receptor–mediated effector functions (ADCC/ADCP)
trial_id_tar_ref
drug_id_tar_ref
disease_id_tar_ref
nct_id_tar_ref
NCT05612581
disease_id_num_tar_ref
2679
drug_id_num_tar_ref
7131